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Antioxidant and Tissue-Protective Studies on Ajwa Extract: Dates from Al-Madinah Al-Monwarah, Saudia Arabia checkpoint kinase 2 (CHEK2), ataxia telangiectasia (A-T) mutated (ATM) protein kinase, and tumor protein fifty three (TP53). Therefore, the present study makes significant contributions to the sector of pure-product based therapeutics in most cancers. Ajwa dates (Phoenix dactylifera L.) are one of the most in style natural fruits that belong to the holy city of Al-Madinah Al-Munawara and its neighboring areas within the Kingdom of Saudi Arabia (KSA). Ajwa date has been described within the conventional and different drugs to offer several well being benefits including anticholesteremic, antidiabetic, anti-inflammatory, antioxidant, hepatoprotective and anticancer results 11,12 . Interestingly, the current research additionally demonstrated that ADP extract mediated each dose- and time-dependent anti-proliferative effects in opposition to HCC cells, whereas having no toxicity against the traditional Vero cell line. A previous study has reported that the date pulp additionally contains phenolics like quercetin and kaempferol 15 , which possess anticancer activity towards HCC cells 26,27 . Thus, it may be postulated that the anticancer effect of ADP extract towards HCC cells might be as a result of synergistic or combined impact of the potential bioactive elements of Ajwa dates.

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